In a recent thread someone was of the view that cows milk was a problem
because some autoimmune disorders might result. To which my reply was
with regard to type 1 diabetes given as an example:
> As to the other issues you raise, could be, there is no concensus on it.
> The diabetes and tie continues to be a matter of no concensus, look at
> that publication date. One can find other studies since that say
> otherwise and which say no or answer not clear, as is so often the case
In which reply a more recent study from 2001 in contrast to the 1994
first example was offered that there is increased risk in those
genetically "susceptible" to type 1 diabetes. This is less then a
universal for all humans risk even if it proves correct. Any
explanation must also account for the great majority of humans who
consume milk and do not get various autoimmune disorders such as type 1
diabetes.
I stand fully by my statement of "could be" with the reasons as
mentioned above. Long before the first 1994 example a connection
between milk as being mentioned the source of some type 1 diabetes was
considered. Here below is info from a 2008 study.
What is im****tant about this, that even now there are mixed results and
no concensus about the question. As shown below there are many possible
sources of type1 diabetes which are reviewed. SAecond the previous
research is reviewed showing as above some say "yes" some say "no" as to
the question of cows milk. This one says "yes" with several
qualifications related to other factors in place.
Of note is mention of the use of a cow milk proteine in an infant
formula which reduced risk of type1 diabetes. That protein was caffeine
which was at the core of the previous thread.
Also as they reviewed the literature they found that gluten and other
cereal sourced proteins also are related to risk of type 1 diabetes.
'Early infant feeding and risk of type 1 diabetes mellitus-a nationwide
population-based case-control study in pre-school children.'
1: Diabetes Metab Res Rev. 2008 Mar-Apr;24(3):211-22. Related Articles,
From the results section:
The risk of type 1 diabetes was inversely related to the duration of
breastfeeding, to children's age at their first exposure to formulas/cow's
milk or solid food, to the amount of current cow's milk intake, to the
family's social status, to the number of children living with the family,
and to the child's rank in the birth order of siblings Feeding of
customary
cow's milk formula during the first year of life was associated with a
significantly increased risk, unlike other kinds of bottle-feeding.
Further, familial type 1 diabetes, older mother's or younger parents' age
at child's birth, low birth weight, single-parent family, and a family's
residence move during recent 2 years (the latter only in tendency) were
related to a higher diabetes risk.
snip
From the discussion section:
This large population-based case-control study in pre-school children
showed that a long duration of breastfeeding, late introduction of bottle
feeding, current cow's milk consumption, higher family's social status,
and
a greater number of children in the family were associated with a reduced
risk of type 1 diabetes, even after adjusting for confounding. Children
with a family history of type 1 diabetes, low birth weight children (<2500
g), and children born to mothers above 40 years of age were shown to bear
a
higher diabetes risk. Estimates of population attributable risks indicated
a short breastfeeding period, an early introduction of bottle feeding, low
or high birth weight (<2500 or 4000 g), and a small family each to account
for 16-23% of diabetic cases in the population. Overall, up to one half of
diabetic cases in the population were potentially attributable to
modifiable exposures.
snip
Earlier retrospective studies did not consistently find evidence for a
protective effect of breastfeeding and late exposure to formulas or cow's
milk [23-27].
Recent prospective investigations, which were not subject to recall bias,
also produced conflicting evidence on the association between infant diet
and the risk of -cell autoimmunity. Some studies did not find an
association between diabetes autoimmunity and breastfeeding duration or
early cow's milk introduction [40-43], whereas other studies did [44][45].
snip
Recently, a randomized double-blind dietary intervention pilot trial in
newborns genetically at increased risk for type 1 diabetes provided first
evidence that casein hydrolysate formulas may protect against the
development of islet cell autoimmunity [47].
Infant diet has been hypothesized to be involved in the initiation of the
type 1 diabetes autoimmune process by impairing the maturation of the
gut-associated immune system and/or by providing antigens cross-reactive
to
islet cell antigens (molecular mimicry) [22]. However, infant diet may
affect diabetes risk as well through pathways according to the recently
raised accelerator hypothesis or the overload hypothesis (e.g. via
increased birth weight, accelerated growth, increased weight gain) [48],
because breast-fed children are well known to show less rapid growth and
to
be less likely to develop childhood adiposity than bottle-fed children
[49]. One study showed both early age at introduction of infant formula
and
increased weight gain to be independently associated with increased
diabetes risk [50].
Results on the association between type 1 diabetes risk and early exposure
to solid foods or current cow's milk intake confirm previous findings
[11][13][19][51], although there are conflicting re****ts [14][27]. The
observed inverse association of current milk intake with social status and
age. Recent prospective studies found associations between increased
ß-cell
autoimmunity and early or late introduction of cereals/gluten or early
introduction of fruits and roots into infant diet [41-43]. Unfortunately,
we had no information on the age at first exposure to different food
categories.
A positive family history of type 1 diabetes has consistently been
re****ted
to raise type 1 diabetes risk among relatives
[2][9][11][20][21][23][51][52]. But re****ted ORs varied considerably,
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